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KMID : 0812020070130020118
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Korean Journal of Neurogastroenterology and Motility
2007 Volume.13 No. 2 p.118 ~ p.122
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Expression of p53 and Ki-67 Protein in Duodenogastric Reflux Gastritis after Subtotal Gastrectomy
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Choi Suck-Chei
Kim Yong-Sung
Kim Ki-Hoon
Kim Hun-Soo
Yun Ki-Jung
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Abstract
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Background/Aims: Duodenogastric reflux of bile and other contents of duodenum is one of the main etiologic fators in chronic gastritis, and chronic inflammation has been recognized as a risk factor of human cancer. The aim of this study was therefore to evaluate the expression of p53 and Ki-67 protein in duodenogastric reflux gastritis.
Methods: To evaluate the proliferation activity and tumor suppressor gene expression, 16 cases of duodenogastric reflux gastritis and 16 cases of control gastric tissue after subtotal gastrectomy were examined immunohistochemically using the monoclonal antibodies to Ki-67 and p53 protein.
Results: The mean duration of follow-up endoscopic biopsy after subtotal gastrectomy was 607 days in duodenogastric reflux gastritis and 556 days in control groups. The mean intensity of Ki-67 in duodenogastric reflux gastritis was significantly higher than that of control tissues (3.0 vs 2.0). The mean intensity of p53 protein in duodenogastric reflux gastritis was significantly higher than that of control tissues (2.0 vs 1.0).
Conclusions: The high expressions of Ki-67 and p53 protein in duodenogastric reflux gastritis may be one of the main mechanisms in the development of gastric stump carcinoma. (Kor J Neurogastroenterol Motil 2007;13:118-122)
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KEYWORD
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Duodenogastric reflux gastritis after subtotal gastrectomy, Ki-67, p53, Gastric stump carcinoma
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